Therapeutic strategies targeting FOXO transcription factors.
Giampaolo CalissiEric Wing-Fai LamWolfgang LinkPublished in: Nature reviews. Drug discovery (2020)
FOXO proteins are transcription factors that are involved in numerous physiological processes and in various pathological conditions, including cardiovascular disease, cancer, diabetes and chronic neurological diseases. For example, FOXO proteins are context-dependent tumour suppressors that are frequently inactivated in human cancers, and FOXO3 is the second most replicated gene associated with extreme human longevity. Therefore, pharmacological manipulation of FOXO proteins is a promising approach to developing therapeutics for cancer and for healthy ageing. In this Review, we overview the role of FOXO proteins in health and disease and discuss the pharmacological approaches to modulate FOXO function.
Keyphrases
- transcription factor
- pi k akt
- signaling pathway
- cardiovascular disease
- endothelial cells
- dna binding
- papillary thyroid
- healthcare
- climate change
- squamous cell carcinoma
- small molecule
- induced pluripotent stem cells
- gene expression
- adipose tissue
- coronary artery disease
- social media
- risk assessment
- young adults
- health information
- insulin resistance