Autocrine insulin-like growth factor 2 signaling as a potential target in the associated development of pulmonary emphysema and cancer in smokers.
Hye-Jin BooHye-Young MinHeung-Bin LimEuni LeeHo-Young LeePublished in: Inflammation and regeneration (2024)
Our work confirms sustained IGF2 signaling activation in AT2s couples impaired lung repair to the concurrent development of emphysema and cancer in mice. Additionally, CCB and IGF2-specific neutralizing antibodies are effective pharmaceuticals for the two diseases.
Keyphrases
- papillary thyroid
- chronic obstructive pulmonary disease
- squamous cell
- lung function
- growth hormone
- pulmonary hypertension
- binding protein
- lymph node metastasis
- smoking cessation
- squamous cell carcinoma
- risk assessment
- pulmonary fibrosis
- radiation therapy
- high fat diet induced
- type diabetes
- locally advanced
- cell proliferation
- climate change
- wild type