Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell.
Caroline S JohnsonAndrew D ChappErin B LindMark J ThomasPaul G MermelsteinPublished in: Biology of sex differences (2023)
Taken together, these data indicate that there are sex differences in the motivated behavior driven by glutamate within the ILC-NAcSh circuit. Though glutamatergic signaling was greater in males, heightened intrinsic excitability in females appears to drive this sex difference.