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Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes.

Maria Jose RedondoAndrea K SteckJay M SosenkoMark AndersonPeter AntinozziAaron W MichelsJohn M WentworthMark A AtkinsonAlberto PuglieseSusan Geyernull null
Published in: Diabetes care (2018)
The type 2 diabetes-associated TCF7L2 locus influences progression of islet autoimmunity, with differential effects by autoantibody specificity and interaction by obesity/overweight.
Keyphrases
  • type diabetes
  • transcription factor
  • insulin resistance
  • weight loss
  • glycemic control
  • weight gain
  • cardiovascular disease
  • metabolic syndrome
  • adipose tissue
  • dna binding
  • genome wide association study