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Thymic mimicry: The art of imitation.

Vanja CabricChrysothemis C Brown
Published in: The Journal of experimental medicine (2023)
Display of tissue self-antigens within the thymus is critical for the regulation of self-reactive T cells. In this issue of JEM, Michelson et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230461) continue to advance our understanding of self-antigen representation by medullary thymic epithelial cells, identifying a new role for Hnf4γ in the regulation of thymic mimetic cells as well as their peripheral counterparts.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • dendritic cells
  • endoplasmic reticulum stress
  • oxidative stress
  • nuclear factor
  • immune response
  • inflammatory response
  • cell proliferation