Early in life stressful events induce chronic visceral pain and changes in bladder function in adult female mice through a mechanism involving TRPV1 and alpha 1A adrenoceptors.

Rita MatosLiliana Santos-LeiteFrancisco CruzAna Charrua

Published in: Neurourology and urodynamics (2024)

MDM induced in female mice is able to mimic IC/BPS phenotype, through mechanisms involving A1AAR and TRPV1. Therefore, the modulation of both receptors may represent a therapeutic approach to treat IC/BPS patients.

Keyphrases

neuropathic pain
end stage renal disease
ejection fraction
newly diagnosed
high fat diet induced
chronic kidney disease
spinal cord injury
chronic pain
prognostic factors
insulin resistance
type diabetes
diabetic rats
high glucose
adipose tissue
oxidative stress
wild type
patient reported