Pharmacogenetics of Dolutegravir Plasma Exposure Among Southern Africans With Human Immunodeficiency Virus.
Zinhle CindiAida N KawumaGary MaartensYuki BradfordFrancois VenterSimiso SokhelaNomathemba ChandiwanaRoeland E WasmannPaolo DentiLubbe WiesnerMarylyn D RitchieDavid W HaasPhumla Z SinxadiPublished in: The Journal of infectious diseases (2022)
In South Africa, rs887829 and rs28899168 in the UGT1A locus were independently associated with dolutegravir AUCVAR. The novel rs28899168 association warrants replication. This study enhances understanding of dolutegravir pharmacogenetics in Africa.