Extremely low dose of 6-mercaptopurine in a Chinese child with acute lymphoblastic leukaemia and multiple pharmacogenetic mutations.

Xiao-Ying ZhaiYue ZhouLei DongAi-Qing NieLi-Juan ZhiEvelyne Jacqz-AigrainTian-You WangLi WangWei Zhao

Published in: Journal of clinical pharmacy and therapeutics (2020)

Complex pharmacogenetic tests and TDM should be recommended in children with complicated ALL to highlight the large individual variability in the responses to 6-MP exposure and the associated adverse effects.

Keyphrases

low dose
liver failure
young adults
respiratory failure
high dose
mental health
drug induced
aortic dissection