Time- and Spectrally-Resolved Photoluminescence Study of Alloyed Cd x Zn 1-x Se y S 1-y /ZnS Quantum Dots and Their Nanocomposites with SPIONs in Living Cells.
Anna MatiushkinaIlia K LitvinovAnastasia BazhenovaTatiana N BelyaevaAliaksei DubavikAndrei V VeniaminovVladimir MaslovElena Sergeevna KornilovaAnna OrlovaPublished in: International journal of molecular sciences (2022)
Magnetic-luminescent composites based on semiconductor quantum dots (QDs) and superparamagnetic iron oxide nanoparticles (SPIONs) can serve as a platform combining visualization and therapy. Here, we report the construction of QD-SPION nanocomposites based on synthesized SPIONs and alloyed QDs (CdxZn1-xSeyS1-y)/ZnS solubilized with L-cysteine molecules. The study of the spectral-luminescence characteristics, the kinetics of luminescence decay show the composite's stability in a solution. After incubation with HeLa cells, QDs, SPIONs, and their composites form clusters on the cell surface and associate with endosomes inside the cells. Component-wise analysis of the photoluminescence decay of cell-associated QDs/SPIONs provides information about their localization and aggregate status.
Keyphrases
- quantum dots
- sensitive detection
- living cells
- induced apoptosis
- iron oxide nanoparticles
- energy transfer
- cell cycle arrest
- fluorescent probe
- reduced graphene oxide
- cell surface
- cell death
- magnetic resonance imaging
- single molecule
- social media
- computed tomography
- stem cells
- signaling pathway
- visible light
- cell proliferation
- gold nanoparticles
- mesenchymal stem cells
- health information
- optical coherence tomography
- room temperature
- simultaneous determination
- ionic liquid