Tetra-PEG Based Hydrogel Sealants for In Vivo Visceral Hemostasis.
Yazhong BuLicheng ZhangGuofei SunFeifei SunJianheng LiuFei YangPeifu TangDe-Cheng WuPublished in: Advanced materials (Deerfield Beach, Fla.) (2019)
Medical sealant devices for in vivo hemostasis are far from satisfactory in the aged society. A major challenge is effective integration of quick hemorrhage control of the increased anticoagulated patients, high safety, and facile accessibility. Here, a well-defined ammonolysis-based Tetra-PEG hydrogel sealant is developed with rapid gelation speed, strong tissue adhesion, and high mechanical strength. Introduction of cyclized succinyl ester groups into a hydrogel matrix endows the sealant with fast degradable and controllably dissolvable properties. The hydrogel possesses outstanding hemostatic capabilities even under the anticoagulated conditions while displaying excellent biocompatibility and feasibility. These results reveal that the optimized hydrogel may be a facile, effective, and safe sealant for hemorrhage control in vivo.
Keyphrases
- drug delivery
- tissue engineering
- hyaluronic acid
- wound healing
- end stage renal disease
- healthcare
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- ejection fraction
- quantum dots
- prognostic factors
- escherichia coli
- gene expression
- genome wide
- staphylococcus aureus
- pseudomonas aeruginosa
- dna methylation
- loop mediated isothermal amplification
- visible light