Hyperuricemia, Gout, and the Brain-an Update.
Augustin LatourteJulien DumurgierClaire PaquetPascal RichettePublished in: Current rheumatology reports (2021)
Observational studies have suggested that patients with hyperuricemia or gout might have a decreased risk of neurodegenerative diseases. Conversely, they may be at increased risk of cerebrovascular disease. Mendelian randomization (MR) studies use a genetic score as an instrumental variable to address the causality of the association between a risk factor (here, UA or gout) and an outcome. So far, MR analyses do not support a causal relationship of UA or gout with Alzheimer's disease and dementia, and of UA with Parkinson's disease or stroke. Observation studies indicate a U-shaped association between UA and brain diseases, but MR studies do not support that this association is causal. Further studies should address the causal role of gout as well as the impact of urate-lowering therapy on these outcomes.
Keyphrases
- uric acid
- case control
- metabolic syndrome
- magnetic resonance
- white matter
- risk factors
- resting state
- atrial fibrillation
- emergency department
- magnetic resonance imaging
- cognitive impairment
- gene expression
- computed tomography
- bone marrow
- cognitive decline
- functional connectivity
- insulin resistance
- electronic health record
- brain injury
- subarachnoid hemorrhage
- adverse drug