WNT5A-RHOA Signaling Is a Driver of Tumorigenesis and Represents a Therapeutically Actionable Vulnerability in Small Cell Lung Cancer.

Kee-Beom Kim Dong-Wook Kim Youngchul Kim Jun Tang Nicole Kirk Yongyu Gan Bongjun Kim Bingliang Fang Jae-Il Park Yi Zheng Kwon-Sik Park

Published in: Cancer research (2022)

The p130-WNT5A-RHOA pathway drives SCLC progression and is a potential target for the development of therapeutic interventions and biomarkers to improve patient treatment.

Keyphrases

small cell lung cancer
cell proliferation
stem cells
climate change
physical activity
case report
human health
combination therapy