Iloprost infusion prevents the insulin-induced reduction in skeletal muscle microvascular blood volume but does not enhance peripheral glucose uptake in type 2 diabetic patients.
Anna L EmanuelNicolien C de ClercqAnnefleur M KoopenErik van PoelgeestMireille J M SerlieDaniel H van RaalteMark H H KramerMax NieuwdorpEtto C EringaErik H SernéPublished in: Diabetes, obesity & metabolism (2018)
Our data suggest that acute improvement in insulin-stimulated muscle perfusion is not an attractive therapeutic approach to bypass cellular resistance to glucose uptake in type 2 diabetes. Whether long-term improvements in insulin-induced muscle perfusion may prove beneficial for glucose disposal remains to be determined.