PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy.

Sylvain SimonValentin VoilletVirginie VignardZhong WuCamille DabrowskiNicolas JouandTiffany BeauvaisAmir KhammariCécile BraudeauRégis JosienOlivier AdotéviCaroline LaheurteFrançois AubinCharles NardinSamuel RulliRaphael GottardoNirasha RamchurrenMartin CheeverSteven P FlingCandice D ChurchPaul NghiemBrigitte DrenoStanley R RiddellNathalie Labarrière

Published in: Journal for immunotherapy of cancer (2021)

Our results provide a convincing rationale for monitoring this PD-1+TIGIT+ circulating population as an early cellular-based marker of therapeutic response to anti-PD-1 therapy.

Keyphrases

genome wide
clinical trial
stem cells
gene expression
dna methylation