Resistance is common in paediatric patients failing ART in South Africa.
Gillian M HuntMukhlid YousifLeon LevinJohanna LedwabaKim SteegenTendesayi KufaHloniphile ZwaneMonalisa KalimasheVibha KanaGetahun AynalemJaclyn PerlmanKassahun AyalewGurpreet KindraKaridia DialloSergio CarmonaGayle ShermanElliot J RaizesPublished in: The Journal of antimicrobial chemotherapy (2023)
HIV drug resistance was highly prevalent in paediatric patients failing ART in South Africa, with 9 in 10 patients harbouring resistance to NNRTIs and/or NRTIs. PI-based regimens are predicted to be highly efficacious in achieving virological suppression amongst patients failing NNRTI-based regimens. Scaling up resistance testing amongst patients would facilitate access to second- and third-line regimens in South Africa.