The aging lung: tissue telomere shortening in health and disease.
Stephanie EveraertsElise J LammertynDries S MartensLaurens J De SadeleerKaren MaesAernoud A van BatenburgRoel GoldschmedingColine H M van MoorselLieven J DupontWim A WuytsRobin VosGhislaine Gayan-RamirezNaftali KaminskiJames C HoggWim JanssensGeert M VerledenTim S NawrotStijn E VerledenJohn E McDonoughBart M VanaudenaerdePublished in: Respiratory research (2018)
These results show a progressive decline in telomere length with age in normal, BOS and RAS lungs. cHP, BOS and RAS lungs demonstrated shorter RTL compared to normal lungs. Lung tissue RTL does not associate with regional disease severity within the lung. Therefore, tissue RTL does not seem to fully reflect peripheral blood telomere length.