Pyrroline-5-Carboxylate Reductase 1: a novel target for sensitizing multiple myeloma cells to bortezomib by inhibition of PRAS40-mediated protein synthesis.
Inge OudaertHatice SatilmisPhilip VlummensWouter De BrouwerAnke MaesDirk HoseElke De BruyneBart GhesquièreKarin VanderkerkenKim De VeirmanEline MenuPublished in: Journal of experimental & clinical cancer research : CR (2022)
This study identifies PYCR1 as a novel target in bortezomib-based combination therapies for MM.