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Pyrroline-5-Carboxylate Reductase 1: a novel target for sensitizing multiple myeloma cells to bortezomib by inhibition of PRAS40-mediated protein synthesis.

Inge OudaertHatice SatilmisPhilip VlummensWouter De BrouwerAnke MaesDirk HoseElke De BruyneBart GhesquièreKarin VanderkerkenKim De VeirmanEline Menu
Published in: Journal of experimental & clinical cancer research : CR (2022)
This study identifies PYCR1 as a novel target in bortezomib-based combination therapies for MM.
Keyphrases
  • multiple myeloma
  • induced apoptosis
  • cell cycle arrest
  • genome wide
  • cell death
  • oxidative stress