Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer.

Hidetaka SuzukiShuichi MitsunagaMasafumi IkedaTakao AoyamaKazumi YoshizawaMasayuki YamaguchiMasami SuzukiMinoru NaritaToshikatsu KawasakiAtsushi Ochiai

Published in: Cancer medicine (2022)

Biological activity of IL-6/gp130 axis promoted N-inv in murine model and was upregulated in PDAC patients with severe N-inv. This study is the first evidence that the IL-6/gp130 axis offers a potential therapeutic target in PDAC with N-inv.

Keyphrases

early onset
cell migration