Pressure-Regulated Single-Entity Electrochemistry Inside Carbon Nanopipettes.

Conductive nanopipettes have been widely used as a multifunctional platform for emerging sensing applications in small spaces, although the electrochemical processes involved are not well controlled and fully quantified. Herein, we use an external pressure to precisely control the solution volume and regulate the electrochemical signals in carbon nanopipettes. In addition to polarizing the redox concentration profile, the pressure is found to generate a convective flow to control the transport processes of redox molecules and nanoparticles as well, and their quantitative correlation is established by a numerical simulation. The elucidated pressure-regulated electrochemistry in conductive nanopipettes would reveal the fundamental charge transport processes at the nanoscale and promote better usage of conductive nanopipettes for delivery and sensing applications in single-cell analysis.