Development of Nanosome-Encapsulated Honokiol for Intravenous Therapy Against Experimental Autoimmune Encephalomyelitis.
Yai-Ping HsiaoHui-Ting ChenYu-Chih LiangTse-En WangKai-Hung HuangCheng-Chih HsuHong-Jen LiangChung-Hsiung HuangTong-Rong JanPublished in: International journal of nanomedicine (2020)
The UHPH method simplified the preparation of NHNK with uniformly distributed nanosize and high encapsulation efficiency. Intravenous administration of NHNK ameliorated the severity of EAE by suppressing the infiltration of activated microglia and Th1 cells into the spinal cord. Collectively, these results suggest that the formulation of NHNK is a prospective therapeutic approach for inflammatory CNS diseases, such as multiple sclerosis.
Keyphrases
- multiple sclerosis
- spinal cord
- induced apoptosis
- high dose
- neuropathic pain
- cell cycle arrest
- oxidative stress
- spinal cord injury
- drug delivery
- blood brain barrier
- inflammatory response
- endoplasmic reticulum stress
- white matter
- cell death
- stem cells
- low dose
- mass spectrometry
- cell proliferation
- high resolution
- neural network
- chemotherapy induced