Rapid clinical mutational testing of KRAS, BRAF and EGFR: a prospective comparative analysis of the Idylla technique with high-throughput next-generation sequencing.

Matthias Van HaeleSara Vander BorghtAn CeulemansMichiel WieërsSofie MetsuXavier SagaertBirgit Weynand

Published in: Journal of clinical pathology (2019)

Our observations demonstrate that the Idylla cartridge for the EGFR, KRAS and BRAF mutations is highly accurate, rapid and has a limited hands-on time compared with next-generation sequencing.

Keyphrases

wild type
small cell lung cancer
high throughput
epidermal growth factor receptor
tyrosine kinase
copy number
loop mediated isothermal amplification
circulating tumor
metastatic colorectal cancer
high resolution
single cell
dna methylation
mass spectrometry