Respiratory and systemic impacts following MWCNT inhalation in B6C3F1/N mice.
Christopher T MigliaccioRaymond F HamiltonPamela K ShawJoseph F RhoderickSanghamitra DebRohit BhargavaJack R HarkemaAndrij HolianPublished in: Particle and fibre toxicology (2021)
The findings in the lungs were consistent with our hypothesis that this MWCNT exposure would result in minimal lung inflammation and injury. However, the low toxicity of the MWCNT to lung macrophages may have contributed to enhanced migration of the MWCNT to the spleen through the lymph nodes, resulting in splenic toxicity and systemic changes in inflammatory mediators.