Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells.

Sarah T BoyleKrystyna A GieniecCarly E GregorJessica W FaulknerShaun R McCollMarina Kochetkova

Published in: Molecular cancer (2017)

Crosstalk between CCR7 and Notch1 promotes stemness in mammary cancer cells and may ultimately potentiate mammary tumor progression. Therefore, dual targeting of both the CCR7 receptor and Notch1 signaling axes may be a potential therapeutic avenue to specifically inhibit the functions of breast cancer stem cells.

Keyphrases

cancer stem cells
dendritic cells
regulatory t cells
stem cells
epithelial mesenchymal transition
cell proliferation
immune response