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Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells.

Sarah T BoyleKrystyna A GieniecCarly E GregorJessica W FaulknerShaun R McCollMarina Kochetkova
Published in: Molecular cancer (2017)
Crosstalk between CCR7 and Notch1 promotes stemness in mammary cancer cells and may ultimately potentiate mammary tumor progression. Therefore, dual targeting of both the CCR7 receptor and Notch1 signaling axes may be a potential therapeutic avenue to specifically inhibit the functions of breast cancer stem cells.
Keyphrases
  • cancer stem cells
  • dendritic cells
  • regulatory t cells
  • stem cells
  • epithelial mesenchymal transition
  • cell proliferation
  • immune response