Use of rituximab in lymphomatoid granulomatosis with isolated central nervous system involvement.
Jesse MooneyhamCesar Giancarlo Gentille SanchezAndrea BarbieriShilpan ShahPublished in: BMJ case reports (2020)
A 33-year-old woman presented to the emergency room with severe headaches. A CT scan of the head revealed two brain lesions with associated vasogenic oedema. Diagnostic resection of one of the lesions followed by pathological analysis revealed grade III lymphomatoid granulomatosis (LYG). Staging investigations elsewhere in the body were negative, isolating this case of LYG to the central nervous system, an atypical presentation. After the resection, she was treated with single-agent rituximab 375 mg/m2 The follow-up MRI demonstrated the resolution of brain lesions and no progression of the disease.
Keyphrases
- computed tomography
- diffuse large b cell lymphoma
- contrast enhanced
- resting state
- white matter
- magnetic resonance imaging
- single cell
- cerebrospinal fluid
- lymph node
- public health
- healthcare
- functional connectivity
- hodgkin lymphoma
- early onset
- cerebral ischemia
- multiple sclerosis
- pet ct
- magnetic resonance
- positron emission tomography