A case report of a patient with inoperable primary diffuse leptomeningeal melanomatosis treated with whole-brain radiotherapy and pembrolizumab.

Patrik PalackaJan SlopovskyMarek MakovnikKarol KajoJana ObertovaMichal Mego

Published in: Medicine (2022)

This is one of the few case reports of an adult patient with this rare malignancy being treated with a programmed death-1 inhibitor with partial response. Immunotherapy in metastatic PDLM may be a reasonable therapeutic option.

Keyphrases

case report
squamous cell carcinoma
locally advanced
small cell lung cancer
early stage
radiation therapy
low grade
resting state
newly diagnosed
advanced non small cell lung cancer
multiple sclerosis
cerebrospinal fluid
radiation induced
brain injury
functional connectivity