A reductively convertible nickel phthalocyanine precursor as a biological thiol-responsive turn-on photoacoustic contrast agent.
Kohei NogitaTakaya SugaharaKoji MikiHuiying MuMinoru KobayashiHiroshi HaradaKouichi OhePublished in: Chemical communications (Cambridge, England) (2024)
A nickel phthalocyanine precursor bearing poly(ethylene glycol) as a turn-on contrast agent for photoacoustic imaging was prepared. The water-soluble polymeric chains were smoothly eliminated through thiol-mediated reductive aromatization in cancer cells, enabling the detection of endogenous biological thiols in vitro and in vivo .
Keyphrases
- water soluble
- photodynamic therapy
- fluorescence imaging
- magnetic resonance
- fluorescent probe
- sensitive detection
- cancer therapy
- living cells
- reduced graphene oxide
- drug delivery
- high resolution
- contrast enhanced
- oxide nanoparticles
- loop mediated isothermal amplification
- carbon nanotubes
- metal organic framework
- label free
- magnetic resonance imaging
- computed tomography
- real time pcr
- drug release
- gold nanoparticles
- single molecule