Ventilation/Perfusion Matching: Of Myths, Mice, and Men.
Alys R ClarkKelly S BurrowesMerryn H TawhaiPublished in: Physiology (Bethesda, Md.) (2020)
Despite a huge range in lung size between species, there is little measured difference in the ability of the lung to provide a well-matched air flow (ventilation) to blood flow (perfusion) at the gas exchange tissue. Here, we consider the remarkable similarities in ventilation/perfusion matching between species through a biophysical lens and consider evidence that matching in large animals is dominated by gravity but in small animals by structure.
Keyphrases
- blood flow
- respiratory failure
- contrast enhanced
- mechanical ventilation
- high fat diet induced
- computed tomography
- intensive care unit
- extracorporeal membrane oxygenation
- room temperature
- genetic diversity
- metabolic syndrome
- type diabetes
- adipose tissue
- acute respiratory distress syndrome
- skeletal muscle
- carbon dioxide