Impaired artery elasticity predicts cardiovascular morbidity and mortality- A longitudinal study in the Vara-Skövde Cohort.
Gábor SzalóMargareta I HellgrenMatthew AllisonYing LiLennart RåstamKarin RådholmEntela BollanoDaniel A DuprezDavid R JacobsUlf LindbladBledar DakaPublished in: Journal of human hypertension (2023)
It is still debated whether arterial elasticity provides prognostic information for cardiovascular risk beyond blood pressure measurements in a healthy population. To investigate the association between arterial elasticity obtained by radial artery pulse wave analysis and risk for cardiovascular diseases (CVD) in men and women. In 2002-2005, 2362 individuals (men=1186, 50.2%) not taking antihypertensive medication were included. C2 (small artery elasticity) was measured using the HDI/Pulse Wave CR2000. Data on acute myocardial infarction or stroke, fatal or non-fatal, was obtained between 2002-2019. Cox- regression was used to investigate associations between C2 and future CVD, adjusting for confounding factors such as age, sex, systolic blood pressure, heart rate, HOMA-IR (Homeostatic Model Assessment for Insulin Resistance), LDL- cholesterol, CRP (C-Reactive Protein), alcohol consumption, smoking and physical activity. At baseline, the mean age of 46 ± 10.6 years and over the follow-up period, we observed 108 events 70 events in men [event rate: 5.9%], 38 in women [event rate: 3.2%]. In the fully adjusted model, and for each quartile decrease in C2, there was a significant increase in the risk for incident CVD by 36%. (HR = 1.36, 95% CI: 1.01-1.82, p = 0.041). The results were accentuated for all men (HR = 1.74, 95% CI: 1.21-2.50, p = 0.003) and women over the age of 50 years (HR = 1.70, 95% CI: 0.69-4.20). We showed a strong and independent association between C2 and CVD in men. In women after menopause, similar tendencies and effect sizes were observed.
Keyphrases
- blood pressure
- heart rate
- polycystic ovary syndrome
- hypertensive patients
- insulin resistance
- alcohol consumption
- acute myocardial infarction
- heart rate variability
- middle aged
- cardiovascular disease
- physical activity
- pregnancy outcomes
- breast cancer risk
- healthcare
- atrial fibrillation
- type diabetes
- left ventricular
- blood glucose
- pregnant women
- emergency department
- percutaneous coronary intervention
- high fat diet
- smoking cessation
- metabolic syndrome
- low density lipoprotein
- brain injury
- depressive symptoms
- big data
- sleep quality
- glycemic control