Neurodegeneration trajectory in pediatric and adult/late DM1: A follow-up MRI study across a decade.
Garazi LabayruAntonio Jimenez-MarinEsther FernándezJorge VillanuaMiren ZulaicaJesus M CortesIbai DiezJorge SepulcreAdolfo López de MunainAndone SistiagaPublished in: Annals of clinical and translational neurology (2020)
Distinct patterns of brain atrophy and its progression over time in pediatric and adult/late onset DM1 patients are suggested. Results indicate a possible neurodevelopmental origin of the brain abnormalities in DM1, along with the possible existence of an additional neurodegenerative process. Fronto-subcortical networks appear to be involved in the disease progression at young adulthood in pediatric onset DM1 patients. The involvement of a multimodal integration network in DM1 is discussed.
Keyphrases
- late onset
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- white matter
- prognostic factors
- glycemic control
- peritoneal dialysis
- type diabetes
- early onset
- young adults
- computed tomography
- multiple sclerosis
- patient reported outcomes
- metabolic syndrome
- brain injury
- childhood cancer
- blood brain barrier
- cerebral ischemia
- functional connectivity
- congenital heart disease
- middle aged