Parent-offspring regression to estimate the heritability of an HIV-1 trait in a realistic setup.

Nadine TschumiTeja TurkClaus KadelkaAlex MarzelMohaned ShilaihJürg BöniVincent AubertThomas KlimkaitGabriel E LeventhalHuldrych F GünthardRoger Kouyosnull null

Published in: Retrovirology (2017)

For conservative transmission pair criteria, both PO regression and mixed-effect models are flexible and robust tools to estimate the contribution of viral genetic effects to viral traits under real-world settings. Overall, we find a strong effect of viral genetics on SPVL that is not confounded by host demographics.

Keyphrases

sars cov
genome wide
antiretroviral therapy
hiv infected
human immunodeficiency virus
hiv positive
high fat diet
hiv testing
dna methylation
gene expression
men who have sex with men
adipose tissue
skeletal muscle
genome wide association