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DNA methylation regulates discrimination of enhancers from promoters through a H3K4me1-H3K4me3 seesaw mechanism.

Ali Sharifi-ZarchiDaniela GerovskaKenjiro AdachiMehdi TotonchiHamid PezeshkRyan J TaftHans R SchölerHamidreza ChitsazMehdi SadeghiHossein BaharvandMarcos Jesus Araúzo-Bravo
Published in: BMC genomics (2017)
Our results show that DNA methylation discriminates promoters from enhancers through H3K4me1-H3K4me3 seesaw mechanism, and suggest its possible function in the inheritance of chromatin marks after cell division. Our analyses suggest aberrant formation of promoter-like regions and ectopic transcription of hypomethylated regions of DNA. Such mechanism process can have important implications in biological process in where it has been reported abnormal DNA methylation status such as cancer and aging.
Keyphrases
  • dna methylation
  • genome wide
  • gene expression
  • transcription factor
  • copy number
  • mitochondrial dna
  • papillary thyroid
  • single cell
  • dna damage
  • stem cells
  • single molecule
  • bone marrow
  • oxidative stress
  • childhood cancer