The Role of Uric Acid in Acute and Chronic Coronary Syndromes.
Alessandro MalobertiMarco BiolcatiGiacomo RuzzenentiValentina GianiFilippo LeidiMassimiliano MonticelliMichela AlgeriSara ScarpelliniStefano NavaFrancesco SorianoJacopo OregliaAlice SaccoNuccia MoriciFabrizio OlivaFederica PianiClaudio BorghiCristina GiannattasioPublished in: Journal of clinical medicine (2021)
Uric acid (UA) is the final product of the catabolism of endogenous and exogenous purine nucleotides. While its association with articular gout and kidney disease has been known for a long time, new data have demonstrated that UA is also related to cardiovascular (CV) diseases. UA has been identified as a significant determinant of many different outcomes, such as all-cause and CV mortality, and also of CV events (mainly Acute Coronary Syndromes (ACS) and even strokes). Furthermore, UA has been related to the development of Heart Failure, and to a higher mortality in decompensated patients, as well as to the onset of atrial fibrillation. After a brief introduction on the general role of UA in CV disorders, this review will be focused on UA's relationship with CV outcomes, as well as on the specific features of patients with ACS and Chronic Coronary Syndrome. Finally, two issues which remain open will be discussed: the first is about the identification of a CV UA cut-off value, while the second concerns the possibility that the pharmacological reduction of UA is able to lower the incidence of CV events.
Keyphrases
- uric acid
- heart failure
- acute coronary syndrome
- metabolic syndrome
- atrial fibrillation
- coronary artery disease
- ejection fraction
- coronary artery
- risk factors
- end stage renal disease
- liver failure
- drug induced
- percutaneous coronary intervention
- cardiovascular events
- left ventricular
- aortic stenosis
- chronic kidney disease
- antiplatelet therapy
- prognostic factors
- insulin resistance
- adipose tissue
- skeletal muscle
- machine learning
- electronic health record
- catheter ablation
- oral anticoagulants
- mitral valve
- case report
- aortic dissection