Endonucleolytic RNA cleavage drives changes in gene expression during the innate immune response.

Agnes KarasikHernan A LorenziAndrew V DePassNicholas R Guydosh

Published in: bioRxiv : the preprint server for biology (2023)

Activated RNase L acts together with other dsRNA-sensing pathways to induce a strong immune response via JNK and p38 signalingGeneric RNA fragmentation plays a key role in inducing transcription, potentially through ribosome collisionsActivation of RNase L inhibits the effects of eIF2α phosphorylationTranslation of the antiviral IFIT mRNAs is inhibited by active RNase L.

Keyphrases

immune response
gene expression
dendritic cells
toll like receptor
signaling pathway
cell death
nucleic acid
transcription factor
induced apoptosis
dna binding
oxidative stress
inflammatory response