A Multiepitope Peptide, rOmp22, Encapsulated in Chitosan-PLGA Nanoparticles as a Candidate Vaccine Against Acinetobacter baumannii Infection.

Xingran DuJianpeng XueMingzi JiangShaoqing LinYuzhen HuangKaili DengLei ShuHanmei XuZeqing LiJing YaoSixia ChenZiyan ShenGanzhu Feng

Published in: International journal of nanomedicine (2021)

CS-PLGA-rOmp22 NPs elicited specific IgG antibodies, Th1 cellular immunity and protection against acute lethal intratracheal A. baumannii challenge. Our results indicate that this nanovaccine is a desirable candidate for preventing A. baumannii infection.

Keyphrases

acinetobacter baumannii
drug delivery
multidrug resistant
drug resistant
pseudomonas aeruginosa
drug release
liver failure
respiratory failure
drug induced
intensive care unit
hepatitis b virus