Resolving the conflicts around Par2 opposing roles in regeneration by comparing immune-mediated and toxic-induced injuries.

Gal RechesNetta R Blondheim ShragaFlorent CarretteAssaf MalkaNatalia SaleevYehuda GubbayOffir ErtrachtIzhak HavivLinda M BradleyFred LevineRon Piran

Published in: Inflammation and regeneration (2022)

We conclude that Par2 activation in the immune system aggravates hepatitis and that Par2 activation in the damaged tissue promotes liver regeneration. When we incorporate this finding and revisit the literature reports, we reconciled the conflicts surrounding Par2's role in injury, recovery, and inflammation.

Keyphrases

stem cells
systematic review
oxidative stress
high glucose
diabetic rats
endothelial cells
adverse drug