Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway.

Zainul Amiruddin ZakariaMohammad Hafiz Abdul RahimMohd Hijaz Mohd SaniMaizatul Hasyima OmarSiew Mooi ChingArifah Abdul KadirQamar Uddin Ahmed

Published in: BMC complementary and alternative medicine (2019)

PECN exerted antinocicpetive activity at peripheral and central levels possibly via the activation of non-selective opioid receptors and modulation of the NO-mediated/cGMP-independent pathway partly via the synergistic action of phenolic compounds.

Keyphrases

chronic pain
nitric oxide
pain management
protein kinase
anti inflammatory
oxidative stress
cancer therapy
drug delivery