Celecoxib-tramadol co-crystal in patients with moderate-to-severe pain following bunionectomy with osteotomy: Secondary analyses by baseline pain intensity and use of rescue medication of a phase 3, randomized, double-blind, factorial, active- and placebo-controlled trial.
Eugene R ViscusiOscar A deLeon-CasasolaJesús CebrecosAdam JacobsAdelaida MorteEsther OrtizMariano SustAnna VaquéIra GottliebStephen DanielsDerek MuseMichael E KussSebastián VidelaNeus GascónCarlos R Plata-SalamánPublished in: Pain practice : the official journal of World Institute of Pain (2024)
Celecoxib-tramadol co-crystal was associated with reduced rescue medication use and an acceptable tolerability profile compared with tramadol or celecoxib alone in adults with acute, moderate-to-severe, postoperative pain.
Keyphrases
- double blind
- postoperative pain
- placebo controlled
- high intensity
- clinical trial
- chronic pain
- phase iii
- phase ii
- drug induced
- open label
- early onset
- study protocol
- pain management
- liver failure
- healthcare
- neuropathic pain
- total knee arthroplasty
- respiratory failure
- emergency department
- spinal cord injury
- aortic dissection
- solid state