The T-type calcium channel antagonist, Z944, reduces spinal excitability and pain hypersensitivity.

Erika K Harding Annemarie Dedek Robert P Bonin Michael W Salter Terrance P Snutch Michael E Hildebrand

Published in: British journal of pharmacology (2021)

T-type calcium channels critically shape the excitability of lamina I pain processing neurons and inhibition of these channels by the clinical stage antagonist Z944 potently reverses pain hypersensitivity across sexes.

Keyphrases

chronic pain
pain management
neuropathic pain
spinal cord
transcranial direct current stimulation
drug induced
postoperative pain
working memory