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Visible-Light-Induced Formation of Thiavinyl 1,3-Dipoles: A Metal-Free [3+2] Oxidative Cyclization with Alkynes as Easy Access to Thiophenes.

Baihui ZhengXiaotong LiYang SongShuyang MengYifei LiQun LiuLing Pan
Published in: Organic letters (2021)
A visible-light-induced [3+2] oxidative cyclization of various alkynes with easily available ketene dithioacetals as the previously unknown thiavinyl 1,3-dipoles in the presence of an acridine photosensitizer is reported. A series of multisubstituted thiophenes were achieved regioselectively in ≤98% yields under very mild metal-free conditions without other additives. This reaction could tolerate a wide range of substrates and achieve good efficiency in large-scale syntheses. The reaction mechanism and their applications are described in detail to reveal the reactivity of the new 1,3-dipoles and the selectivity of the reactions.
Keyphrases
  • visible light
  • photodynamic therapy
  • high glucose
  • diabetic rats
  • genome wide
  • ionic liquid
  • drug induced
  • electron transfer
  • oxidative stress
  • endothelial cells
  • gene expression
  • dna methylation