Adipose-derived mesenchymal stromal cell-derived exosomes promote tendon healing by activating both SMAD1/5/9 and SMAD2/3.

Hengchen LiuMingzhao ZhangManyu ShiTingting ZhangWenjun LuShulong YangQingbo CuiZhaozhu Li

Published in: Stem cell research & therapy (2021)

Overall, we demonstrated that ADSC-Exos contributed to tendon regeneration and provided proof of concept of a new approach for treating tendon injuries.

Keyphrases

stem cells
anterior cruciate ligament reconstruction
rotator cuff
epithelial mesenchymal transition
bone marrow
transforming growth factor
mesenchymal stem cells
signaling pathway
wound healing