Immune suppression caused by PD-L2 expression on tumor cells in gastric cancer.

Yuko NakayamaKousaku MimuraLey-Fang KuaHirokazu OkayamaAung Kyi Thar MinKatsuharu SaitoHiroyuki HanayamaYohei WatanabeMotonobu SaitoTomoyuki MommaZenichiro SazeShinji OhkiYoshiyuki SuzukiDaisuke IchikawaWei-Peng YongKoji Kono

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2020)

PD-L2 is expressed on GC cells and PD-1/PD-L2 interaction are functionally involved in anti-tumor CTL activities. PD-L2 expression should be considered when determining the optimal immunotherapy for GC.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
oxidative stress
cell death