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Atomistic Characterization of Beta-2-Glycoprotein I Domain V Interaction with Anionic Membranes.

Hale S HasdemirNicola PozziEmad Tajkhorshid
Published in: bioRxiv : the preprint server for biology (2024)
GPI's DV and anionic membranes, crucial for APS pathogenesis. It highlights the importance of specific regions in DV for membrane binding and reveals a predominant bind-ing mode. These findings have significant implications for APS diagnostics and therapeutics, offering a deeper insight into the molecular basis of the syndrome.
Keyphrases
  • molecular dynamics simulations
  • small molecule
  • case report
  • transcription factor