Clinical Accuracy of Serum Neurofilament Light to Differentiate Frontotemporal Dementia from Primary Psychiatric Disorders is Age-Dependent.
Victoria LightSherri Lee JonesElham RahmeKaterine RousseauSterre de BoerLisa VermuntMahdie SoltaninejadCharlotte TeunissenYolande PijnenburgSimon DucharmeFor Signature ConsortiumPublished in: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry (2024)
PPD have mildly elevated sNfL compared to healthy subjects but much lower than bvFTD. Results support the use of sNfL as a biomarker to differentiate PPD from bvFTD at age 60 or below, but accuracy decreases in older ages.