Development and validation of a gas chromatography/tandem mass spectrometry method for simultaneous quantitation of several antipsychotics in human plasma and oral fluid.
Tiago RosadoDavid OppolzerBelinda CruzMário BarrosoSamira VarelaVictor OliveiraCarlos LeitãoEugenia GallardoPublished in: Rapid communications in mass spectrometry : RCM (2018)
The described method was proven selective and sensitive for the determination of antipsychotics in low sample volumes using SPE and GC/MS/MS. This method was considered suitable not only for routine analysis of patients undergoing antipsychotic treatment (to evaluate compliance), but also in forensic scenarios where the studied compounds may be involved. To the best of our knowledge, this is the first work that reports the determination of antipsychotic drugs in oral fluid using MS/MS.
Keyphrases
- tandem mass spectrometry
- gas chromatography
- solid phase extraction
- ultra high performance liquid chromatography
- ms ms
- high performance liquid chromatography
- liquid chromatography tandem mass spectrometry
- liquid chromatography
- simultaneous determination
- molecularly imprinted
- mass spectrometry
- gas chromatography mass spectrometry
- high resolution mass spectrometry
- patients undergoing
- high resolution
- healthcare
- climate change
- emergency department
- clinical practice
- smoking cessation