NRAS Q61R immunohistochemical staining in thyroid pathology: sensitivity, specificity and utility.

Maelle SalibaNora KatabiSnjezana Dogan Ronald A GhosseinRonald A Ghossein

Published in: Histopathology (2021)

NRAS Q61R IHC is highly sensitive and specific for the detection of RAS Q61R mutations in thyroid pathology and is particularly relevant in follicular-patterned neoplasms. When evaluated alongside histological features, NRAS Q61R immunoreactivity can be instrumental in the diagnosis and classification of thyroid nodules.

Keyphrases

wild type
machine learning
deep learning
loop mediated isothermal amplification
fluorescent probe
high resolution
mass spectrometry
flow cytometry
sensitive detection