Extracellular HMGB1 exacerbates autoimmune progression and recurrence of type 1 diabetes by impairing regulatory T cell stability.

Jing Zhang Longmin ChenFaxi WangYuan ZouJingyi LiJiahui LuoFaheem KhanFei SunYang LiJing LiuZhishui ChenShu ZhangFei XiongQilin YuJinxiu LiKun HuangBao-Ling AdamZhiguang ZhouDecio L EizirikPing YangCong-Yi Wang

Published in: Diabetologia (2020)

The present data support the possibility that HMGB1 could be a viable therapeutic target to prevent the initiation, progression and recurrence of autoimmunity in the setting of type 1 diabetes.

Keyphrases

type diabetes
free survival
transcription factor
glycemic control
big data
data analysis
artificial intelligence