Altered birefringence of peripapillary retinal nerve fiber layer in multiple sclerosis measured by polarization sensitive optical coherence tomography.

This is the first study using PS-OCT to study the pRNFL birefringence in MS patients. Decreased birefringence of the pRNFL may indicate microtubule abnormality, and could be a potential biomarker for detecting early neurodegeneration in MS.