GMP production of 6-[18F]Fluoro-L-DOPA for PET/CT imaging by different synthetic routes: a three center experience.
Valdemar L AndersenMikkel A SoerensenJohan Hygum DamNiels LangkjaerHenrik PetersenDirk Andreas BenderDan FugloeTri Hien Viet HuynhPublished in: EJNMMI radiopharmacy and chemistry (2021)
For most sites either of the two nucleophilic substitution strategies should be favored. However, which of the two will depend on whether a given site wishes to optimize the radiochemical yield or the ease of the use.