In Multiple Myeloma, High-Risk Secondary Genetic Events Observed at Relapse Are Present From Diagnosis in Tiny, Undetectable Subclonal Populations.

Romain Lannes Mehmet Kemal Samur Aurore PerrotCeline MazzottiMarion DivouxTitouan CazaubielXavier Leleu Anaïs SchavgoulidzeMarie-Lorraine ChretienSalomon ManierDidier AdikoFrederique Orsini-PiocelleFrançois LifermannSabine BrechignacLauris GastaudDidier BouscaryMargaret MacroAlice CleynenMohamad Mohty Nikhil C Munshi Jill Corre Herve Avet-Loiseau

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)

These data suggest that identifying these scarce aggressive cells may necessitate more aggressive treatment as early as diagnosis to prevent them from becoming the dominant clone.

Keyphrases

multiple myeloma
induced apoptosis
cell cycle arrest
electronic health record
genome wide
big data
gene expression
copy number
machine learning
signaling pathway
combination therapy
endoplasmic reticulum stress
free survival
cell proliferation
pi k akt