Role of Deubiquitinases in Human Cancers: Potential Targeted Therapy.
Keng Po LaiJian ChenWilliam Ka Fai TsePublished in: International journal of molecular sciences (2020)
Deubiquitinases (DUBs) are involved in various cellular functions. They deconjugate ubiquitin (UBQ) from ubiquitylated substrates to regulate their activity and stability. Studies on the roles of deubiquitylation have been conducted in various cancers to identify the carcinogenic roles of DUBs. In this review, we evaluate the biological roles of DUBs in cancer, including proliferation, cell cycle control, apoptosis, the DNA damage response, tumor suppression, oncogenesis, and metastasis. This review mainly focuses on the regulation of different downstream effectors and pathways via biochemical regulation and posttranslational modifications. We summarize the relationship between DUBs and human cancers and discuss the potential of DUBs as therapeutic targets for cancer treatment. This review also provides basic knowledge of DUBs in the development of cancers and highlights the importance of DUBs in cancer biology.
Keyphrases
- cell cycle
- dna damage response
- endothelial cells
- papillary thyroid
- childhood cancer
- cell proliferation
- healthcare
- squamous cell
- induced pluripotent stem cells
- oxidative stress
- endoplasmic reticulum stress
- cell death
- small molecule
- dna repair
- human health
- lymph node metastasis
- risk assessment
- climate change
- pi k akt
- case control